Diltiazem cream for anal fissure

On ano-health.eu you can find more information about anal fissures and order a diltiazem cream that will be compounded specifically for you. Our goal is to offer accurate information and a product that should be available to everyone, but isn’t.

Anal fissures represent one of the most common anorectal conditions encountered in medical practice. It affects people of various age groups and it can severely deteriorate their quality of life. Based on chronology and symptoms present, the anal fissure can be classified as acute or chronic. Anal fissures rarely heal spontaneously. In most cases, they require medical attention. Various agents have been proposed for the treatment of anal fissure. The aim of most of them is to promote the relaxation of the internal anal-sphincter muscle. Clinical evidence has shown that the spasm of the internal anal sphincter leads to reduction of blood flow in the area. This sets the right conditions for the appearance of painful and long-lasting ischemic ulcers (which is what anal fissures are). Relaxation can be achieved by several surgical techniques, such as anal dilatation or lateral internal sphincterotomy. However, the surgical approach is associated with increased risks, especially the risk of permanent fecal incontinence due to the weakening of the anal sphincter.

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The role of diltiazem in treatment of anal fissures

During the past decades, many clinical studies have shown the positive effect of medical treatment with calcium-channel blockers (such as diltiazem or nifidipine). Diltiazem (DTZ) is primarily used in the treatment of hypertension and some types of arrhythmia. It relaxes the smooth muscles in the walls of arteries, which improves the blood flow and lowers the blood pressure. The idea is that diltiazem ointment applied locally can be used to lower the resting anal pressure and promote fissure healing. The agent is available as oral preparation and in topical form. Studies have shown that the topical treatment with 2% diltiazem cream is much more effective and it will promote healing in about 70% of the chronic anal fissures. However, its use for treatment of anal fissure isn’t licensed in most countries, which means there isn’t a market product that you can buy over-the-counter to help yourself.

In most cases, a diltiazem cream is prescribed by a knowledgeable coloproctologist/surgeon and then prepared for the patient by a compounding pharmacy. Unfortunately, many doctors (especially general practitioners) and pharmacies are not up to the task and might waste your time. And time is important when it comes to treatment of anal fissure.

Moreover, a study conducted by M. Shah in 2009 shows that half the patients who have been prescribed diltiazem for treatment of anal fissure, received a substandard formulations of topical 2% diltiazem.

The diltiazem cream that you can order from us is going to be prepared carefully, according to a formula approved and used by pharmaceutical societies in the UK and Spain. This product has already reached hundreds of people. We have sent a short questionnaire to each of our clients. Not everyone responds, but from these who did nearly 80% have stated that the cream had a positive effect on their wellbeing and 68% claimed to be fissure-free after one month of usage. The only adverse reactions reported were headache (4%) and itching (11%), which are to be expected as cited in the medical literature. These outcomes are very favorable in terms of efficacy, given that the surgical alternatives come with increased risk of fecal incontinence.

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